Quotation Zitterl, Werner , Aigner, Martin, Stompe, Thomas, Zitterl-Eglseer, Karin, Wenzel, Thomas, Gutierrez-Lobos, Karin, Schmidl-Mohl, Brigitte, Demal, Ulrike, Zettinig, Georg, Hornik, Kurt, Thau, Kenneth. 2007. [123i]-β-CIT SPECT Imaging Shows Reduced Thalamus-Hypothalamus Serotonin Transporter Availability in 24 Drug-Free Obsessive-Compulsive Checkers. Neuropharmapsychology 32 (8): 1661-1668.


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Abstract

Numerous findings indicate alterations in brain serotonin systems in obsessive-compulsive disorder (OCD). We investigated the in vivo availability of thalamus–hypothalamus serotonin transporters (SERT) in patients with DSM-IV OCD who displayed prominent behavioral checking compulsions (OC-checkers). Four hours after injection of [123I]-2-carbomethoxy-3-(4-iodophenyl)tropane ([123I]--CIT), single photon emission computed tomography (SPECT) scans were performed in 24 medication-free non-depressed OC-checkers and 24 age- and gender-matched healthy controls. For quantification of brain serotonin transporter availability, a ratio of specific to non-displaceable [123I]--CIT brain binding was used (V"3=(thalamus and hypothalamus-cerebellum)/cerebellum). Drug-free non-depressed OC-checkers showed an 18% reduced brain serotonin transporter availability in the thalamus and hypothalamus, as compared with healthy control subjects (1.380.19 vs 1.690.21; p<0.001). There was a strong negative correlation between severity of OC symptomatology (Y-BOCS scores) and SERT availability (r=-0.80; p<0.001). Moreover, we found a significant positive correlation between illness duration and serotonin transporter availability (r=0.43; p<0.05). This first report of significantly reduced [123I]--CIT binding in the thalamus–hypothalamus region in OC-checkers suggests reduced brain serotonin transporter availability, which is more pronounced with increased severity of OC symptomatology and short duration of illness. The results provide direct evidence for an involvement of the serotonergic system in the pathophysiology of OCD.

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Publication's profile

Status of publication Published
Affiliation WU
Type of publication Journal article
Journal Neuropharmapsychology
Citation Index SCI
Language English
Title [123i]-&#946;-CIT SPECT Imaging Shows Reduced Thalamus-Hypothalamus Serotonin Transporter Availability in 24 Drug-Free Obsessive-Compulsive Checkers
Volume 32
Number 8
Year 2007
Page from 1661
Page to 1668

Associations

People
Hornik, Kurt (Details)
External
Aigner, Martin (Austria)
Demal, Ulrike
Gutierrez-Lobos, Karin (Austria)
Schmidl-Mohl, Brigitte
Stompe, Thomas (Austria)
Thau, Kenneth
Wenzel, Thomas
Zettinig, Georg
Zitterl, Werner (Department of Psychiatry, mdical University of Vienna, Austria)
Zitterl-Eglseer, Karin (Austria)
Organization
Institute for Statistics and Mathematics IN (Details)
Research Institute for Computational Methods FI (Details)
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